Mood & Stress Resilience Insight Report
Original price was: $49.$29Current price is: $29.
Cognitive Performance Insight Report
Original price was: $49.$29Current price is: $29.
Skin Health & Regeneration Insight Report
Original price was: $49.$29Current price is: $29.
Muscle Hypertrophy Insight Report
Original price was: $49.$29Current price is: $29.
Energy Metabolism Insight Report
Original price was: $49.$29Current price is: $29.
Original price was: $49.$29Current price is: $29.
Inflammation & Immune Modulation
Fourteen validated markers across IL-1 and IL-6 signaling, TNF-alpha tone, bacterial sensing, vitamin-D-driven immunity and barrier function — the largest panel in the range, read from the raw DNA file you already have. Not guessed.
$29 $49Save $20
One-time payment · digital delivery · no subscription
NuGenia Logics · Molecular Insight Engine
Sample · anonymized
Low alignment across fourteen markers — the widest panel in the range. Two clear signals (IL-6 tone, vitamin-D receptor) sit inside an otherwise ordinary immune profile, and the report says which is which.
Peptide alignment · 8 compounds scored
Analyzed from the raw file you already have.
Fourteen markers mapped to immune and inflammatory biology.
Scored, explained, and delivered digitally.
The questions it answers
Four questions about where your inflammatory set point actually sits — not a diagnosis, and not an inflammation “score” of the kind sold with a supplement bundle attached. The answers are already in the file you downloaded from your DNA testing service.
IL6 at rs1800795 sits in the promoter of interleukin-6, the cytokine that drives longer-lasting inflammation rather than the acute burst. TNF at rs1800629 and two IL1B variants set the intensity of the acute side. Together they describe a set point, not an event.
IL6 rs1800795TNF rs1800629
VDR at rs731236 is your vitamin D receptor — and LL-37, one of your body’s own antimicrobial peptides, depends on vitamin-D/VDR signaling to be produced at all. Reduced receptor signaling means a blood level in range may not be doing everything you assume it is.
VDR rs731236TaqI
TLR4 at rs4986790 and rs1927911 is the receptor that detects bacterial LPS — the first-line sensor sitting at your gut and airway barriers. FCGR2A at rs1801274 governs immune-complex clearance. This is the recognition layer, upstream of everything else.
TLR4 rs4986790FCGR2A rs1801274
This is the section most people buy the report for. Eight compounds studied in this pathway are scored against your markers — and in the sample below three of the eight return no alignment at all, while the top match is a peptide your own body already makes.
8 compounds scored+ full alignment table
See the report
This isn’t an “inflammation score” with a supplement bundle attached. It’s a personalized analysis of fourteen genetic markers and how they relate to cytokine tone, bacterial sensing and vitamin-D-driven immunity — and everything on the right is lifted from a real delivered report.
Your report includes:
NuGenia Logics · Molecular Insight Engine
Low alignment
“Your results suggest a solid natural baseline in this pathway, with a few clear areas where inflammation tone, barrier support, and vitamin-D-linked immune signaling are worth keeping steady through consistent daily habits.”
Compounds studied in this pathway, ranked against your markers.
Supported by your markers: rs16944rs1800795rs1927911rs731236
Moderate support
Single-marker evidence
Moderate support
Single-marker evidence
Low relevance
No supporting markers in this profile
No alignment
This is the widest panel we run, and here is what an honest wide panel looks like: in this sample, six of the fourteen markers came back as the common pattern with nothing to act on beyond the basics. Two carried real signal — a higher IL-6 tone and reduced vitamin-D receptor signaling — and the report says which two rather than dramatizing all fourteen. Three of the eight compounds return no alignment at all. A panel that finds something urgent in every marker is not a better panel; it is a worse one.
How to read it
Your score describes how closely your variants match the compounds studied in this pathway. It is a measure of relevance to your genetics — not a measure of how healthy you are.
80+
Many of your variants match the peptides studied here. This is the pathway most worth exploring with a licensed provider, and where targeted support is most likely to be relevant to you.
55–79
A partial match. Some compounds here may be relevant to you, particularly alongside consistent sleep, training and nutrition habits rather than instead of them.
<55
Few of your variants match these targets — frequently a sign of a strong natural baseline in this pathway. Lower relevance here is not a deficiency, and it is a legitimate, useful answer.
Marker by marker
All fourteen marker cards follow the same three-part form, so nothing arrives as jargon you have to decode yourself.
What it is
What your result means
What you can do about it
What this means for you
IL-6 is a key driver of longer-lasting inflammation. The GG pattern at this IL-6 promoter position is studied in relation to higher IL-6 activity.
What this means for you
VDR is your vitamin D receptor, and your antimicrobial peptide LL-37 depends on vitamin-D/VDR signaling to be produced. The AA pattern is associated with reduced VDR signaling — a lower baseline for vitamin-D-driven innate immunity.
What this means for you
Two copies of the variant, associated with a reduced response to bacterial (LPS) signaling.
Coverage
The widest panel in the range — and the full list is published here rather than summarised, including the markers that most often come back unremarkable. Every one is reliably present in consumer raw-data files. See which file formats we read →
| Gene | Variant | System | What it governs |
|---|---|---|---|
| IL6 | rs1800795 | Inflammatory tone | The −174 promoter variant — IL-6 activity, the cytokine behind longer-lasting rather than acute inflammation. One of the two markers carrying real signal in the sample above. |
| VDR | rs731236 | Vitamin D immunity | The TaqI variant — vitamin D receptor signaling, which your own antimicrobial peptide LL-37 depends on. The second marker carrying real signal in the sample. |
| TNF | rs1800629 | Acute inflammation | The −308 promoter variant — TNF-alpha production, the master switch of the acute inflammatory response. |
| IL1B | rs16944 | IL-1 dial | A promoter variant setting baseline IL-1 beta signaling — the intensity dial on acute inflammation. |
| IL1B | rs1143634 | IL-1 intensity | A second IL-1 beta variant, read alongside rs16944 because the pair is more informative than either alone. |
| TLR4 | rs4986790 | Bacterial sensing | The Asp299Gly variant — how strongly your first-line sensor responds to bacterial LPS at the gut and airway barrier. |
| TLR4 | rs1927911 | Barrier signaling | A second TLR4 variant covering the barrier-signaling side of the same receptor. |
| FCGR2A | rs1801274 | Immune clearance | The His131Arg variant — receptor sensitivity for clearing immune complexes, the cleanup arm of the response. |
| OXTR | rs53576 | Stress & inflammation | The oxytocin receptor — studied in relation to baseline inflammation and stress reactivity, which is why a social-connection marker appears on an immune panel. |
| SLC15A1 | rs2297322 | Peptide transport | Intestinal peptide-transport efficiency — part of the gut-barrier picture. |
| MC1R | rs1805007 | Melanocortin | One of three MC1R variants read together. The melanocortin system has anti-inflammatory signaling roles alongside its better-known pigmentation function. |
| MC1R | rs1805008 | Melanocortin | The second of the three MC1R variants. |
| MC1R | rs1805009 | Melanocortin | The third MC1R variant. All three commonly return the standard pattern, and the report says so when they do. |
| MC4R | rs17782313 | Metabolic link | A variant near MC4R — the metabolic side of melanocortin signaling, included because metabolic state feeds inflammatory tone. |
Methodology
NuGenia’s Molecular Insight Engine™ matches your genotypes against a curated, versioned rule set for inflammatory and immune biology and computes the score arithmetically. Most DNA-interpretation products pass your genotypes to a language model and print whatever comes back. That is not what happens here.
23andMe, AncestryDNA, MyHeritage or FamilyTreeDNA
Target markers located and validated
Genotypes matched against curated rules
Compounds ranked against your markers
Delivered as a private link
Determinism is the whole point. Run your file through this engine today and again next year and you get an identical result — because your genome did not change, and neither did the arithmetic. Any product that cannot promise that is generating text, not analyzing data. You can read more about how the engine works in The Science.
Compounds scored
Eight compounds are studied in this pathway — the longest list in the range. Your report scores each against your markers and names the exact variants behind every call, including the three that came back with nothing. The top match, LL-37, is notable for being a peptide your body already produces on its own, provided the vitamin-D signaling it depends on is working.
None of these compounds treats or prevents any infection, autoimmune condition, or inflammatory disease, and none should be used in place of medical care. LL-37, KPV, TB-500, ARA-290, Semax and Selank are research compounds, not approved medicines in the US or UK; TB-500 is additionally prohibited in competitive sport by WADA. Peptide alignment is educational context to discuss with a licensed provider — not a recommendation, prescription, or suggestion to obtain any compound. An alignment score describes your genetics, not whether a compound is safe, legal, available, or appropriate for you.
Reference material for each compound lives in the Peptide Database.
Questions
No. This report analyzes the raw data file you can already download from 23andMe, AncestryDNA, MyHeritage or FamilyTreeDNA. No new kit, no new sample, no additional lab work. If you have tested with any of those services, your file is already sufficient — see the Raw DNA File Format Reference.
A 0–100 measure of how closely your specific genetic variants match the biological targets of the eight compounds studied in this pathway. A high score means many of your markers sit in the systems those compounds act on. A low score means few of them do — often a sign of a strong natural baseline.
It measures relevance to your genetics, not how healthy you are, and it is not a recommendation to take anything.
No. It cannot, and it does not try to. These fourteen markers describe ordinary variation in cytokine signaling, bacterial sensing and vitamin-D-driven immunity across the entire population. They are not diagnostic, they are not a risk score, and no combination of them indicates rheumatoid arthritis, lupus, IBD, coeliac disease or any other condition.
Inflammation is measured — CRP, ESR, cytokine panels, and the clinical picture — not inferred from a genotype. If you have joint pain, gut symptoms, unexplained fatigue or anything else that worries you, please see a doctor rather than buying a $29 report and hoping it explains it.
The scoring is not. Your genotypes are matched against a curated, versioned rule set and the score is arithmetic on those matches, so the same file always produces the same result. That determinism is deliberate, and it is the main technical difference between this report and products that pass your genotypes to a language model and print the output.
Upload instructions are sent right after checkout. If you want to see the process first, the How to Upload Your DNA guide walks through downloading your raw file from each testing service.
Your raw DNA file is used for one thing: generating your report. As soon as processing finishes, the file is erased from our systems. We do not keep it on file, we do not build a database of customer genomes, and we do not sell or share your genetic data with third parties.
What remains afterward is your finished report and your normal order record — not the underlying file. Full details are in our Privacy Policy.
Because the pathways genuinely differ in how much well-replicated evidence exists. Inflammation and immunity have been studied across many independent cytokine and receptor genes, so there is more worth reading. Muscle hypertrophy has four markers with deep replication behind them and a long tail of weak candidates we deliberately leave out.
We would rather publish four solid markers than pad a panel to look impressive — and we would rather run fourteen where fourteen are warranted. More markers is not automatically a better report, and the price is the same either way, which removes any incentive to inflate the count.
That is exactly the leap this report is careful not to make for you, because the honest answer depends on a blood level it cannot see. A VDR variant describes how your receptor responds to vitamin D — it does not tell you your current status, and taking more is not automatically the right response. Vitamin D is fat-soluble and genuinely possible to overdo.
The useful move is to get 25-hydroxyvitamin D measured and take that result, plus this one, to your doctor. That is a real conversation with two pieces of information in it. Dosing yourself from a genotype alone is not.
Yes, and it is written to be handed over. Every marker card names the gene, the rsID and your genotype, and the report includes a methodology and references section so a clinician can evaluate the basis for each interpretation rather than take it on faith.
See Refunds & Returns, or start a refund request.
Yes. A complete sample report is available at nugenialogics.com/sample-report — the same format you receive, with every section intact.
Get your report
Upload the raw data file you already have and get a personalized Inflammation & Immune Modulation Insight Report — no new test, no subscription, no recurring anything.
Insight Report · SKU RPT-6201
Secure checkout · Digital delivery · See a full sample or contact us before you buy.
These are genetic tendencies, not a diagnosis. NuGenia Logics reports are for research, educational and informational use only and do not diagnose, treat, cure or prevent any disease. Genetic associations are population-level and probabilistic. Do not start, stop or change any supplement, peptide, medication or health practice based on this report — always consult a qualified, licensed healthcare provider. Peptides referenced are discussed as research areas only; peptide alignment is not a recommendation or prescription. These statements have not been evaluated by the Food and Drug Administration. See our Research Use Disclaimer and Terms of Use.
Reviews
There are no reviews yet.
Only logged in customers who have purchased this product may leave a review.