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Sleep & Recovery Regulation
Six validated markers across circadian timing, melatonin signaling, mitochondrial defense, muscle-fiber type and stress clearance — read from the raw DNA file you already have, and scored against the compounds studied in this pathway. Not guessed.
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NuGenia Logics · Molecular Insight Engine
Sample · anonymized
Moderate alignment. A partial match — some compounds studied here line up with this member’s markers, alongside consistent habits rather than instead of them.
Peptide alignment · 7 compounds scored
Analyzed from the raw file you already have.
Six markers mapped to sleep and recovery biology.
Scored, explained, and delivered digitally.
The questions it answers
Four questions that explain why the same bedtime works for one person and not another — and the answers are already in the file you downloaded from your DNA testing service.
CLOCK at rs1801260 is one of the most replicated variants in human chronotype research — it shifts your natural sleep timing earlier or later. MTNR1B at rs10830963 sets how your melatonin receptor responds to that signal. Together they explain why an 11pm bedtime is effortless for some people and a nightly fight for others.
CLOCK rs1801260MTNR1B rs10830963
SOD2 at rs4880 governs how efficiently your primary mitochondrial antioxidant enzyme reaches the mitochondria — the machinery that does the actual repair work while you sleep. Recovery is not only about hours in bed; it is about what those hours are able to accomplish.
SOD2 rs4880Ala16Val
ACTN3 at rs1815739 shapes your muscle-fiber profile and therefore how much recovery a hard session actually costs you. COMT at rs4680 sets how fast you clear adrenaline afterward. Training load and sleep quality are the same conversation.
ACTN3 rs1815739COMT rs4680
This is the section most people buy the report for. Seven compounds studied in this pathway are scored against your markers — and in the sample below, four of the seven come back with no alignment at all.
7 compounds scored+ full alignment table
See the report
This isn’t a generic sleep-hygiene guide. It’s a personalized analysis of your genetic markers and how they relate to sleep timing, overnight repair and recovery capacity — and everything on the right is lifted from a real delivered report.
Your report includes:
NuGenia Logics · Molecular Insight Engine
Moderate alignment
“You show a solid natural recovery baseline with generally steady sleep signaling, with your main opportunity centered on keeping circadian timing consistent.”
Compounds studied in this pathway, ranked against your markers.
Supported by your markers: rs1815739
Moderate support
Single-marker evidence
Moderate support
Single-marker evidence
Low relevance
No supporting markers in this profile
No alignment
This is a moderate result, and it is shown here unedited. Three of the seven compounds scored register any support at all — and four come back with no alignment whatsoever. A sales-driven engine would not return that. The scoring has no commercial incentive built into it: it reports the alignment your markers actually produce, including the four times in this single report that the honest answer was “this one is not for you.”
How to read it
Your score describes how closely your variants match the compounds studied in this pathway. It is a measure of relevance to your genetics — not a measure of how healthy you are.
80+
Many of your variants match the peptides studied here. This is the pathway most worth exploring with a licensed provider, and where targeted support is most likely to be relevant to you.
55–79
A partial match. Some compounds here may be relevant to you, particularly alongside consistent sleep, training and nutrition habits rather than instead of them.
<55
Few of your variants match these targets — frequently a sign of a strong natural baseline in this pathway. Lower relevance here is not a deficiency, and it is a legitimate, useful answer.
Marker by marker
All six marker cards follow the same three-part form, so nothing arrives as jargon you have to decode yourself.
What it is
What your result means
What you can do about it
What this means for you
One copy of the evening-associated CLOCK variant — a mild tendency toward later sleep timing.
What this means for you
SOD2 protects your mitochondria from oxidative stress. The GG pattern is associated with efficient delivery of this antioxidant enzyme to the mitochondria — a favorable recovery profile.
What this means for you
MC3R sits at the intersection of energy balance and circadian rhythm. The GG pattern is studied in relation to altered signaling that may shift the timing of your sleep and energy cycles.
Coverage
Six markers, each with deep replication behind it, rather than a long list padded for appearances. Every one is reliably present in consumer raw-data files. See which file formats we read →
| Gene | Variant | System | What it governs |
|---|---|---|---|
| CLOCK | rs1801260 | Chronotype | The 3111T/C variant — one of the most replicated markers in human chronotype research, associated with how early or late your natural sleep window falls. |
| MTNR1B | rs10830963 | Melatonin | Melatonin receptor 1B — how your tissues respond to the melatonin signal, and therefore how cleanly you transition into deep sleep. |
| SOD2 | rs4880 | Cellular repair | The Ala16Val variant — how efficiently your primary mitochondrial antioxidant enzyme reaches the mitochondria, where overnight repair happens. |
| MC3R | rs3827103 | Circadian energy | Melanocortin 3 receptor — the link between energy balance and circadian rhythm, where meal timing feeds back into the body clock. |
| ACTN3 | rs1815739 | Recovery load | The R577X variant — muscle-fiber composition, which sets how much recovery a hard training session actually costs you. |
| COMT | rs4680 | Stress reset | Catechol-O-methyltransferase — how fast adrenaline and dopamine are cleared after stress, and therefore how quickly you can wind down. |
Methodology
NuGenia’s Molecular Insight Engine™ matches your genotypes against a curated, versioned rule set for sleep and recovery biology and computes the score arithmetically. Most DNA-interpretation products pass your genotypes to a language model and print whatever comes back. That is not what happens here.
23andMe, AncestryDNA, MyHeritage or FamilyTreeDNA
Target markers located and validated
Genotypes matched against curated rules
Compounds ranked against your markers
Delivered as a private link
Determinism is the whole point. Run your file through this engine today and again next year and you get an identical result — because your genome did not change, and neither did the arithmetic. Any product that cannot promise that is generating text, not analyzing data. You can read more about how the engine works in The Science.
Compounds scored
Seven compounds are studied in this pathway. Your report scores each against your markers and names the exact variants behind every call, so nothing is asserted without evidence you can check — including the calls that come back as no alignment.
Peptide alignment is educational context to discuss with a licensed provider — not a recommendation, prescription, or suggestion to obtain any compound.
Reference material for each compound lives in the Peptide Database.
Questions
No. This report analyzes the raw data file you can already download from 23andMe, AncestryDNA, MyHeritage or FamilyTreeDNA. No new kit, no new sample, no additional lab work. If you have tested with any of those services, your file is already sufficient — see the Raw DNA File Format Reference.
A 0–100 measure of how closely your specific genetic variants match the biological targets of the seven compounds studied in this pathway. A high score means many of your markers sit in the systems those compounds act on. A low score means few of them do — often a sign of a strong natural baseline.
It measures relevance to your genetics, not how healthy you are, and it is not a recommendation to take anything.
No, and it is not capable of it. These six markers describe ordinary variation in sleep timing, melatonin response and recovery capacity across the whole population — they are not diagnostic of anything, and no combination of them indicates a sleep disorder. Sleep apnea in particular is a structural and physiological condition that no DNA file can detect. If you snore heavily, wake unrefreshed, or suspect a sleep disorder, that is a conversation for a qualified clinician and likely a sleep study.
The scoring is not. Your genotypes are matched against a curated, versioned rule set and the score is arithmetic on those matches, so the same file always produces the same result. That determinism is deliberate, and it is the main technical difference between this report and products that pass your genotypes to a language model and print the output.
Upload instructions are sent right after checkout. If you want to see the process first, the How to Upload Your DNA guide walks through downloading your raw file from each testing service.
Your raw DNA file is used for one thing: generating your report. As soon as processing finishes, the file is erased from our systems. We do not keep it on file, we do not build a database of customer genomes, and we do not sell or share your genetic data with third parties.
What remains afterward is your finished report and your normal order record — not the underlying file. Full details are in our Privacy Policy.
No, and it is not permitted to. The report shows how closely each compound studied in this pathway aligns with your markers, and names the specific variants behind each call — in the sample above, melatonin returns no alignment at all. What you do with that is a conversation for you and a licensed healthcare provider. See our Research Use Disclaimer.
They answer different questions. Your wearable measures what happened last night — how long you slept, how restlessly, roughly which stages. This describes the biology underneath, which does not change night to night: where your natural sleep window falls, how your melatonin receptor responds, how efficiently your cells repair. A wearable tells you that last night was poor. This helps explain why a given schedule keeps producing poor nights for you specifically. They complement each other; neither replaces the other.
Yes, and it is written to be handed over. Every marker card names the gene, the rsID and your genotype, and the report includes a methodology and references section so a clinician can evaluate the basis for each interpretation rather than take it on faith.
See Refunds & Returns, or start a refund request.
Yes. A complete sample report is available at nugenialogics.com/sample-report — the same format you receive, with every section intact.
Get your report
Upload the raw data file you already have and get a personalized Sleep & Recovery Regulation Insight Report — no new test, no subscription, no recurring anything.
Insight Report · SKU RPT-6206
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These are genetic tendencies, not a diagnosis. NuGenia Logics reports are for research, educational and informational use only and do not diagnose, treat, cure or prevent any disease. Genetic associations are population-level and probabilistic. Do not start, stop or change any supplement, peptide, medication or health practice based on this report — always consult a qualified, licensed healthcare provider. Peptides referenced are discussed as research areas only; peptide alignment is not a recommendation or prescription. These statements have not been evaluated by the Food and Drug Administration. See our Research Use Disclaimer and Terms of Use.
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